A Textbook of Modern Toxicology, 4th Edition by Ernest Hodgson

By Ernest Hodgson

A Textbook of recent Toxicology is a distinct source that gives either scholars and practitioners with a wide-ranging, available evaluation of the self-discipline. appropriate for classes in environmental, pharmacological, scientific, and veterinary toxicology, this crucial textual content gains chapters written via specialists who handle quite a number key topics.The Fourth version comprises extra chapters on new ways to toxicology - molecular tools (-omics: toxicogenomics, proteomics, and metabolomics), bioinformatics, and platforms biology – and keeps the legacy of its predecessors to supply up to date insights into acute toxicity and chemical carcinogenesis, organ toxicity, in vitro and in vivo toxicity checking out, ecological probability overview, and lots of different components of toxicology that support foster a great comprehension of the field.Also featured within the Fourth version are end-of-chapter questions and a options guide to be had individually for tutorial adopters.

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Extra info for A Textbook of Modern Toxicology, 4th Edition

Example text

These aspects, concerned with the formulation of laws, and regulations authorized by laws, are intended to minimize the effect of toxic chemicals on human health and the environment. 1. Legal aspects are the formulation of laws and regulations and their enforcement. In the United States, enforcement falls under such government agencies as the Environmental Protection Agency (EPA), the Food and Drug Administration (FDA) and the Occupational Safety and Health Administration (OSHA). Similar government agencies exist in many other countries.

E. Hodgson. New York: Wiley, 2004. status and mitochondrial function as well as the intracellular concentration of sulfhydryl groups, Ca2+, H+, Na+, and K+. Toxicity to cultured cells may be the result either of inadequacies in the culture or the toxicity effects of the chemical being investigated. 1. Longer-term assessments of cell toxicity are highly dependent upon the relevant toxic end point. They may include measurement of growth competence, apoptosis, and/or necrosis, incorporation of radioactive precursors into essential cellular constituents such as RNA, DNA, and protein and specialized cellular functions.

C. Smart and E. Hodgson. Hoboken, NJ: Wiley, 2008. SAMPLE QUESTIONS 1. Briefly discuss the importance of cultured cell techniques in toxicology. 2. Define the following terms: a. Northern and Southern blot analysis; b. Polymerase chain reaction; c. Microarray. 3. Define the following terms: a. Western blot; b. Polyclonal and monoclonal antibodies; c. Immunoaffinity purification and immunoprecipitation. PART II CLASSES OF TOXICANTS CHAPTER 3 Exposure Classes, Toxicants in Air, Water, Soil, Domestic, and Occupational Settings W.

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