Aging and Cell Structure: Volume 2 by Robert O. Kelley, Kathryn G. Vogel (auth.), John E. Johnson

By Robert O. Kelley, Kathryn G. Vogel (auth.), John E. Johnson Jr. (eds.)

Although hundreds of thousands of articles and hundreds and hundreds of books on getting older were released, just a small percent of this fabric has handled anatomy, quite on the effective­ structural point. It used to be with this in brain that getting older and phone constitution was once conceived. quantity 1 of getting older and mobilephone constitution was once released in 1981 and represented a present compilation of data, concentrating on the electron microscopic point, on morphological alterations which happen in cells and tissues as they age. the current quantity completes the two-volume set. whereas quantity 1 highlighted structural adjustments taking place within the getting older apprehensive process, quantity 2 facilities its efforts on experiences of in vitro getting older. Chapters on different topics are incorporated besides. those contain age-related adjustments visible in neuromuscular junctions, oral tissues, and the pancreas. even supposing those volumes signify a really small a part of the broadcast infor­ mation on experimental gerontology, their strategy is very particular simply because they specialise in anatomy, probably the main simple of the entire biomedical sciences. simply because many dif­ ferent tissue kinds are tested, we start to work out recurrent, definitive styles within the getting older telephone which could now not be absolutely obvious from reports taking one phone variety at a time. This turns into much more obvious within the current quantity the place alterations noticeable in popula­ tions of cells grown in culture-isolated from hormones or apprehensive impulses from different physique areas-are stumbled on to be just like these adjustments present in vivo.

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Continued investigation of the subtle alterations in these components which accompany cellular aging could result in a generalized understanding of factors which regulate the formation and function of external cell surfaces. And finally, although both early- and late-passage cells exhibit a prominent cytoskeleton, variation in spreading and contact behavior between age-related culture groups correlates (1) with alterations in organization of cytoskeletal components, and (2) with the establishment of actin bundles and detergent-resistant membrane regions following reseeding of cells on culture substrates.

USA 73:4526. Bosmann, H. , Gutheil, R. , and Case, K. , 1976, Loss of a critical neutral protease in ageing WI-38 cells, Nature 261:499. Bowman, P. , Meek, R. , and Daniel, C. , 1975, Aging of human fibroblasts in vitro: Correlations between DNA synthetic ability and cell size, Exp. Cell Res. 93:84. , 1966, Fracture faces of frozen membranes, Proc. Natl. Acad. Sci. USA 55:1048. , Gilula, N. , Karnovsky, M. , Staehelin, L. , and Weinstein, R. , 1975, Freeze-etching nomenclature, Science 190:54. Bretscher, M.

USA 74:3883. Herzenberg, L. , and Herzenberg, L. , 1978, Analysis and separation using the fluorescence activated cell sorter (FACS), in: Handbook of Experimental Immunology, Vol. 3 (D. M. ), pp. 21, Blackwell Scientific Publications, London. 33 34 ROBERT O. KELLEY and KA THRYN G. VOGEL Hynes, R. , and Bye, J. , 1974, Density and cell cycle dependence of cell surface proteins in hamster fibroblasts, Cell 3:113. Johnson, J. , 1979, Fine structure of IMR-90 cells in culture as examined by scanning and transmission electron microscopy, Mech.

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