By Douglas W. P. Hay (auth.), Dr. David Raeburn, Dr. Mark A. Giembycz (eds.)
Read or Download Airways Smooth Muscle: Peptide Receptors, Ion Channels and Signal Transduction PDF
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Additional info for Airways Smooth Muscle: Peptide Receptors, Ion Channels and Signal Transduction
142. Cioffi CL, Neale RF Jr, Jackson RH, Sills MA. Characterization of rat lung endothelin receptor subtypes which are coupled to phosphoinositide hydrolysis. J. Pharmacol Exp. Ther. 1992; 262: 611-8. 143. Kobayashi M, Ihara M, Sato N, Saeki T, Ozaki S, Ikemoto F et al. A novel ligand, [ 125IjBQ-3020, reveals the localization of endothelin ET B receptors. Eur. J. Pharmacol. 1993; 234: 95-100. 144. Henry PJ.
Maggi CA, Giuliani S, Patacchini R, Rovero P, Giachetti A, Meli A. The activity of peptides of the endothelin family in various mammalian smooth muscle preparations. Eur. J. Pharmacoi. 1989; 174: 23-31. 95. Maggi CA, Giuliani S, Patacchini R, Santicioli P, Rovero P, Giachetti A. The C-terminal hexapeptide, endothelin-(16-21), discriminates between different endothelin receptors. Eur. J. Pharmacoi. 1989; 166: 121-2. 96. Maggi CA, Giuliani S, Patacchini R, Santicioli P, Giachetti A, Me1i A. Further studies on the response of the guinea-pig isolated bronchus to endothelins and sarafotoxin S6b.
In addition, there was a significant correlation between ET -1 levels and several haemodynamic and respiratory parameters, including mean pulmonary arterial pressure and airway resistance . In lung tissue from patients with cryptogenic fibrosing alveoli tis (CFA), a fatal condition of unknown cause which is characterized by 34 D. W. P. Hay inflammation, type II pneumocyte and fibroblastic proliferation, and collagen deposition, there was markedly increased expression of ET -1, most notably in airway epithelium and type II pneumocytes, compared with control tissue or tissues from patients with focal fibrosis .