By Stephen K. Tyring
Not like the other resource at the topic, Antiviral brokers, Vaccines, and Immunotherapies analyzes the advantages and boundaries of each to be had drug, vaccine, and immunotherapy used in the prevention and regulate of viral ailments. This reference offers in-depth experiences of greater than 50 medicines and antiviral brokers for HIV, human herpesviruses, human papillomaviruses (HPV), influenza, respiration syncytial virus, hepatitis B, and analyzes their mechanisms of motion, dosage, unwanted side effects, and drug resistance. The booklet additionally presents an outline of using immunoglobulins and monoclonal antibodies for antiviral use and provides wide references, tables, and figures in the course of the textual content.
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Additional info for Antiviral Agents, Vaccines and Immunotherapies
Renal tubular dysfunction has occurred in at least one patient (72). Mucocutaneous responses. Occasional erythema, macules, and papules have been observed in patients taking d4T (65). Esophageal ulcers are also rarely seen. Lipoatrophy. Lipoatrophy is associated with mitochondrial toxicity, lactic acidemia, and insulin resistance. Switching from stavudine or zidovudine to abacavir can lead to modest increases in limb fat, but clinical lipoatrophy does not resolve (73–75). Neuromuscular weakness/respiratory failure.
Robbins, V. W. Snyder, and R. D’Aquila. 2003. ” N Engl J Med 349: 2304–2315. 14. De Clercq, E. 2002. New anti-HIV agents and targets. Med Res Reviews 22: 531–565. 15. Anonymous. 2003. ” MMWR 52: 1155–1157. 16. Enserink, M. 2003. ” Science 302: 1141–1142. Chapter 2 Antiretroviral Drugs to Treat Human Immunodeﬁciency Virus Infections INTRODUCTION In less than two decades, human immunodeﬁciency virus (HIV) has dramatically progressed from a little-known or understood infection to the cause of a major global epidemic.
Rebound of viral load levels during consistent treatment may indicate resistant HIV variants and may likely require changes in the current antiretroviral regimen. It should be noted that if one of the drugs in the antiretroviral regimen must be stopped, they all should be stopped and that a single-drug substitution can be made only if the patient’s viral load is completely suppressed. Antiretroviral Drugs to Treat Human Immunodeﬁciency Virus Infections 39 NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS Nucleoside analogs were the ﬁrst line of defense for the treatment of HIV infection in 1987 (36).