Benzene - A Medical Dictionary, Bibliography, and Annotated by Icon Health Publications

By Icon Health Publications

This can be a 3-in-1 reference ebook. It offers a whole scientific dictionary protecting thousands of phrases and expressions on the subject of benzene. It additionally supplies huge lists of bibliographic citations. ultimately, it presents info to clients on find out how to replace their wisdom utilizing quite a few web assets. The booklet is designed for physicians, scientific scholars getting ready for Board examinations, clinical researchers, and sufferers who are looking to get to grips with examine devoted to benzene. in case your time is effective, this ebook is for you. First, you won't waste time looking the net whereas lacking loads of proper details. moment, the ebook additionally saves you time indexing and defining entries. ultimately, you won't waste time and cash printing countless numbers of web content.

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One of the major tumor suppressor genes characterized in mammalian systems is p53 and a high percentage of leukemias contain mutations or allelic losses of p53. In preliminary data, we demonstrate that NQO1 forms a protein complex with wild type p53. We propose to examine whether the interaction of NQO1 and p53 is specific for wild type p53 and whether it has consequences for p53 stability and p53-dependent transcriptional activation of downstream genes. If NQO1 stabilizes p53 and the interaction has functional consequences, this would provide a mechanism for the increased incidence of leukemia of diverse origin that has been associated with a lack of NQO1 protein due to the NQO1*2 polymorphism.

Determine dose-dependent effects of benzene and its metabolites in formation and persistence of oxidized DNA bases and co-valent DNA adducts as well as production of 3-nitro tyrosine and etheno-base adducts and their relationships with cytotoxicity. 3 (II) Investigate whether C57BI/6AiTAC (KO)Nos2 mice (deficient in iNOS) are protected against benzene induced bone marrow suppression. The results of this study will provide detailed information on the mechanisms and the nature of the DNA lesions that are responsible for benzene toxicity; such knowledge is of paramount importance for risk assessment.

4 Angstrom units extended DNA bases are proposed. It is hypothesized that DNA strands completely comprised of such analogues will be competent in hybridizing to natural RNA or DNA complements. Moreover, it is predicted that because of greatly enhanced base stacking, the binding will exhibit higher affinity and pairing specificity than natural DNA does. Further, a number of these extended bases are expected to be fluorescent, allowing for the possibility that they can act as self-reporters of helix formation.

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