Cancer Biomarkers in Body Fluids: Biomarkers in Circulation by Gabriel D. Dakubo

By Gabriel D. Dakubo

This e-book examines intensive the proof, medical functions and strength melanoma signatures within the flow and discusses changes in circulating cell-free nucleic acids, and circulating tumor DNA, in addition to the epigenome, genome, transcriptome (coding and noncoding), proteome (both conventional serum proteins and proteomic profiles) and metabolome. extra, it highlights the medical functions of circulating tumor cells for every melanoma style and addresses the rising significance of extracellular vesicular contents, together with miRNA, oncogenes and drug resistant components. As such, it bargains a invaluable reference consultant for melanoma researchers, oncologists, clinicians, surgeons, clinical scholars, oncology nurses, diagnostic laboratories, and the pharmaceutical industry.

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Also clonal evolution with metastasis could lead to emergence of clones not expressing the marker used for detection. • CMCs cannot be enumerated for predictive clinical use, but quantification, which may mirror target copy numbers and possible number of cells, may overcome this limitation. • Leukocyte nucleic acids could dilute CMC targets, which could result in false negative results. • There is lack of analytical standardization leading to inconsistent results even when the same target is being assayed.

89]) was predictive of OS and time to progression [90]. Another supporting evidence of the fact that serum VEGF levels are high in melanoma patients was provided by Pelletier et al. [91]. Here, significant differences were observed between stage I–III and stage IV patients. Baseline VEGF levels were not elevated in those who relapsed. 1 %), and this finding had a specificity of 78 %. , absence of elevated VEGF) [91]. High serum VEGF is associated with shorter disease-free survival (DFS) compared to those with lower levels (median DFS of 25 months vs.

Melanoma inhibitory activity protein is characterized as an autocrine growth inhibitory factor. It interacts with the extracellular matrix and cell adhesion receptors. In functional studies, increased expression in transfected melanoma cell lines resulted in acquisition of invasive and metastatic phenotypes. It also interacts with integrin α4β1 on leukocytes, interfering with their anticancer immune functions. Various studies suggest serum MIA has utility in clinical staging of melanoma, detection of disease progression from localized to invasive stages, and for monitoring response to therapy in advanced stage melanoma.

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