Current Concepts in Autoimmunity and Chronic Inflammation by Andreas Radbruch, Peter E. Lipsky

By Andreas Radbruch, Peter E. Lipsky

The ethiopathologies of autoimmune illnesses are advanced. A large number of cellphone varieties and gene items are concerned. even though, scientific and experimental facts means that the significance of someone issue adjustments in the course of the process the ailment. components and telephone forms that result in acute autoreactivity and start up an autoimmune affliction can be particular from those who force a protracted process that sickness.

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Extra info for Current Concepts in Autoimmunity and Chronic Inflammation (Current Topics in Microbiology and Immunology)

Sample text

Adjuvant emulsions without bacterial material, such as incomplete Freund’s adjuvant, not only failed to produce disease but even conferred protection from induction of autoimmunity. As has been recognized in the meantime, it is the microbial component that activates APCs close to the immunization site and within the local lymph tissues by binding to toll-like receptors. This response makes the APCs produce a spectrum of pro-inflammatory mediators, which together signal the autoreactive T cell (which may have recognized its autoantigen in proper MHC context on the surface of the APC) to become autoaggressive, to produce disease (Lanzavecchia and Sallusto 2001).

Nature 337:562–566 Rolink A, Grawunder U, Haasner D, Strasser A, Melchers F (1993) Immature surface Ig+ B cells can continue to rearrange kappa and lambda L chain gene loci. J Exp Med 178:1263–1270 Rolink AG, Brocker T, Bluethmann H, Kosco-Vilbois MH, Andersson J, Melchers F (1999) Mutations affecting either generation or survival of cells influence the pool size of mature B cells. Immunity 10:619–628 B Cell Tolerance—How to Make It and How to Break It 23 Rolink AG, Schaniel C, Andersson J, Melchers F (2001) Selection events operating at various stages in B cell development.

38 Autoantigen Retrouvé: Recognition/Presentation in the Target Organ . . 39 6 Conclusion . . . . . . . . . . . . . . . . . . . . . . 44 References . . . . . . . . . . . . . . . . . . . . . . . . . 45 Abstract Immunological self-tolerance is maintained through diverse mechanisms, including deletion of autoreactive immune cells following confrontation with autoantigen in the thymus or in the periphery and active suppression by regulatory cells.

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