Cytochrome P450 by Michael R. Waterman, Eric F. Johnson (Eds.)

By Michael R. Waterman, Eric F. Johnson (Eds.)

This quantity represents the 1st selection of methodological ways to P450 research such as using molecular organic suggestions. it truly is designed to be used by means of those that examine the P450 tremendous relations. tools are provided for the identity and characterization of targeted kinds of P450 mRNA and protein, for expression of P450s in heterologous structures, for the learn of human P450s, and for the characterization of P450s in several tissues

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32-35This protein contains six cysteine residues, of which four act as ligands for the Fe2S 2 iron-sulfur redox center. The C-terminal tryptophan of putidaredoxin is essential for maximal biological activity, 36,37 and this residue has been suggested to lie near a carboxylate-based binding surface implicated in 22 j. A. Peterson, I. Yuzuru, and B. W. Griffin, Arch. Biochem. Biophys. 149, 197 (1972). 23 L. Eisenstein, P. Debey, and P. Douzou, Biochem. Biophys. Res. Commun. 77, 1377 (1977). 24 W.

Groves, G. A. McCluskey, R. E. White, and M. J. Coon, Biochem. Biophys. Res. Commun. 81, 154 (1978). 28 j. D. Lipscomb, S. G. Sligar, M. J. Namtvedt, and I. C. Gunsalus, J. Biol. Chem. 251, 1116 (1976). 29 W. M. Atkins and S. G. Sligar, J. Am. Chem. Soc. 109, 3754 (1987). 3o L. D. Gorsky, D. R. Koop, and M. J. Coon, J. Biol. Chem. 259, 6812 (1984). 31 C. A. Tyson, J. D. Lipscomb, and I. C. Gunsalus, J. Biol. Chem. 247, 5777 (1972). 32 T. C. Pederson, R. H. Austin, and I. C. Gunsalus, in "Microsomes and Drug Oxidations" (V.

Black, J. Biol. Chem. 264, 4442 0989). 7 C. Chothia and A. M. Lesk, EMBO J. 5, 819 (1986). [2] MODELINGP450S ON BASISOF P450cam STRUCTURE 15 There is no distinction made between interior and exterior regions but only those regions which deviate by less than 3/k. An alternative definition uses only solvent-inaccessible residues, thereby excluding surface residues. 8 Since the structural core is likely to be less susceptible to amino acid substitutions, this method gives lower rms deviations. 5 ,~.

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