Cytokeratins - tools in oncology by Gerhard Hamilton

By Gerhard Hamilton

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1995; Wildi, Kleeff et al. 1999; Zhou, Toivola et al. 2003; Schutte, Henfling et al. 2004; Toivola, Krishnan et al. 2004; Moll, Divo et al. 2008; Omary, Ku et al. 2009; Habtezion, Toivola et al. 2011) while there are also some reports stating the absence of this CK in the intestine (Ramaekers, Huysmans et al. 1987; Oriolo, Wald et al. 2007). Several type I cytokeratins are present in intestinal epithelial cells. e. CK18, these cells also contains CK19 and CK20. Presence of multiple type I cytokeratins is not redundant as gene replacement studies have shown that defect in any type I cytokeratin may lead to defect in the cells morphology and function.

1990). " Journal of Microscopy-Oxford 157: 91-104. Vessey, C. J. and P. D. L. M. Hall (2001). " Pathology 33(2): 130141. , J. Kleeff, et al. (1999). " Clinical Cancer Research 5(10): 2840-2847. , S. W. French, et al. (2007). " Experimental Cell Research 313(10): 2033-2049. Zhong, B. , P. Strnad, et al. (2009). " Hepatology 50(2): 546554. , M. Cadrin, et al. (2006). " Journal of Biological Chemistry 281(24): 1645316461. , D. M. Toivola, et al. (2003). " Molecular Biology of the Cell 14(7): 29592971.

CK7 expression is also seen in hepatocytes in these conditions. This has been interpreted as in vivo evidence that progenitor cells can differentiate into ductular cells and mature hepatocytes in response to the chronic liver injury associated with these diseases, in contrast to the previously held view that mature hepatocytes at the limiting plate transform via metaplasia into biliary ductal cells. The degree of bile ductular reaction, progenitor cell numbers and proportion of hepatocytes expressing CK7 increases in parallel with disease grade (activity) and stage (Eleazar, Memeo et al.

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