Dopaminergic Ergot Derivatives and Motor Function. by Kjell Fuxe and Donald B. Calne (Eds.)

By Kjell Fuxe and Donald B. Calne (Eds.)

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Additional resources for Dopaminergic Ergot Derivatives and Motor Function. Proceedings of an International Symposium Held in the Wenner–Gren Center, Stockholm, July 24–25, 1978

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148, 143 (1978). 54. T. J. Jessell, Inhibition of substance P release from the isolated rat substantia nigra by GABA, Br. J, Pharmacol. 59, 486P (1977). 55. -C. Reubi, L. L. Iversen and T. M. Jessell, Dopamine selectively increases ^ H - G A B A release from slices of rat substantia nigra in vitro, Nature 268, 652 (1977). 56. M. J. Brownstein, E. A. Mroz, J. S. Kizer, and M. Palkovits, Regional distribution of substance P in the brain of the rat, Brain Res. 116, 299 (1976). 57. J. Liebschutz, L.

F. ), Academic Press, New York (1965); P. Stadler and P. Stütz, The Alkaloids, XV p. F. ), Academic Press, New York (1975). 2. A. Hofmann, Die Mutterkornalkaloide, F. Enke, Stuttgart (1964). 32 H. Hauth 3. J. A. Stadler in Ergot Alkaloids and Related Compounds, Handbook of Pharmacology 49 p. 29, B. O. ), Springer-Verlag, Berlin (1978). 4. See Chemical Abstracts 9th Coll. Index, Index Guide 76-85 (1972- 1976T: 5. A. Stadler, P. Stütz and E. Stürmer, Experientia 33, 1552 (1977). 6. E. M. R. Wagner in Progress in Prolactin Physiology and Pathology p.

GABA (or the enzyme responsible for its biosynthesis, glutamic acid decarboxylase) is found in both the striatum and the pallidum. In the striatum it seems to be present in interneuronsl5 and in neurons whose axons project to other regions of the brain. 16 The compact part of the nigra is innervated by neurons in the caudal third of the anterior striatum and the rostral third of the pallidum. The reticular part of the nigra is innervated by somewhat more caudally placed neurons. Substance P. 16,17 More than 50% of these neurons are in the rostral half of the anterior striatum, an area that has few, if any, GABAergic neurons projecting to the sub- Biochemical Anatomy of the Extrapyramidal System 35 sxantia nigra.

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