By Bruce Anderson, Ann de Peyster, Shayne C. Gad, P.J. Bert Hakkinen, Michael Kamrin, Betty Locey, Harihara M. Mehendale, Carey Pope, Lee Shugart, Philip Wexler
The second one version of the Encyclopedia of Toxicology maintains its finished survey of toxicology. This new version keeps to provide entries dedicated to key strategies and particular chemical compounds. there was a rise in entries dedicated to overseas companies and famous toxic-related incidents reminiscent of Love Canal and Chernobyl. in addition to the normal scientifically established entries, new articles concentrate on the societal implications of toxicological wisdom together with environmental crimes, chemical and organic conflict in precedent days, and a background of the U.S. environmental circulate.
With greater than 1150 entries, this moment version has been multiplied in size, breadth and intensity, and gives an in depth review of the various points of toxicology.
Also to be had on-line through ScienceDirect - that includes wide shopping, looking out, and inner cross-referencing among articles within the paintings, plus dynamic linking to magazine articles and summary databases, making navigation versatile and straightforward. for additional information, pricing suggestions and availability stopover at www.info.sciencedirect.com.
*Second variation has been accelerated to four volumes
*Encyclopedic A-Z association of chemical substances and all middle parts of the technological know-how of toxicology
*Covers similar parts equivalent to companies, poisonous injuries, old and social matters, and laws
*New subject matters lined comprise computational toxicology, melanoma efficiency components, chemical injuries, non-lethal chemical guns, medicinal drugs of abuse, and patron items and lots of extra!
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Additional info for Encyclopedia of Toxicology Second Edition
It is a numerical estimate of daily oral exposure to the human population, including sensitive subgroups such as children, that is not likely to cause harmful effects during a lifetime. The ADI is expressed in milligrams of the chemical, as it appears in the food, per kilogram of body weight per day (mg kg À 1 day À 1). The Environmental Protection Agency (EPA) refers to such an exposure level as the risk reference dose (RfD) in order to avoid any implication that any exposure to a toxic material is ‘acceptable’.
Mechanism of Toxicity Retinoids increase cellular mitotic activity, DNA and RNA synthesis, and protein synthesis. The primary toxicity of concern is female-mediated teratogenesis. Isotretinoin alters cell differentiation and placement in developing fetuses that are exposed to it in the first 3 weeks. Any exposed fetus has an increased change of spontaneously aborting or dying and may develop external or internal abnormalities. Cases of IQ less than 85 have been reported without other noted abnormalities.
CHEMICAL ABSTRACTS SERVICE REGISTRY NUMBER: CAS 83-32-9 SYNONYMS: 1,2-Dihydroacenaphthylene; 1,8-Dihydroacenaphthalene; 1,8-Ethylenenaphthalene; Acenaphthylene; Naphthyleneethylene; Periethylenenaphthalene; Ethylenenaphthylene CHEMICAL/PHARMACEUTICAL/OTHER CLASS: Arene belonging to the class of polycyclic aromatic hydrocarbons CHEMICAL STRUCTURE: Background Information Acenaphthene is a component of crude oil and a product of combustion, which may be produced and released to the environment during natural fires.