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Additional info for Endocrine Disruptors 2012
Toole developed assays and investigated kinase, phosphatase, methylase inhibitors and activators, utilizing a microfluidic platform (Caliper) while at Amphora Discovery in RTP, North Carolina. She was Team Leader for the AKT project. As Director of Molecular Biology at Cayman Chemical Company, she initiated and directed the molecular biology/protein expression core group. She was later named Manager of Preclinical Drug Discovery for Cayman Chemical. Dr. Toole has extensive experience in assay development utilizing various readouts including luminescence, absorbance, fluorescence, fluorescence polarization, FRET, TR-FRET and microfluidics.
Thus, the burden of proof will be on the operator to prove that the exposure to humans is negligible. 2013) • Directive > Regulation, a more harmonized implementation of the regulatory framework as not need for a transposition period or for national transposition measures in MS. , representatives from the 27 MS), have to reach an agreement on the COM’s proposal • Council proposed the following amendment to COM’s proposal; The commission shall adopt, by means of a delegated act adopted in accordance with Article 72a, measures specifying scientific criteria for the determination of endocrine disrupting properties.
OECD activities on ED testing and assessment 5. ECETOC activities 6. EFSA activities 7. Smart Testing strategies 05 January 2012 Paper 4 - Neale Page 4 of 26 pages Endocrine Disruptors 2012 14-15 February 2012 – Munich, Germany Slide 3 LKC Switzerland Ltd Based in the heart of Europe with affliates in the UK, Switzerland, USA and Japan Extensive EU regulatory expertise and scientific knowledge Strong background of registrations for exisiting and new chemicals Specialisation in the development of proven successful regulatory strategies Successful longterm partnership with clients 05 January 2012 Slide 4 Client Base /Industry Representation • Multinational Research and Development Chemical Companies • Interest in Plant Protection Products (PPPs), Biocides and Speciality Chemicals • Develop and Register their compounds globally –main focus on Europe, USA and Japan 05 January 2012 Page 5 of 26 pages Paper 4 - Neale 14-15 February 2012 – Munich, Germany Endocrine Disruptors 2012 Slide 5 Endocrine Disruptors (EDs) – Questions asked?