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Extra info for High Density Lipoproteins: From Biological Understanding to Clinical Exploitation (Handbook of Experimental Pharmacology)
Johnson, Gunda Reddy Contents Introduction Environmental fate and transport Summary of Mammalian Toxicity Mammalian oral toxicity: acute/subacute Mammalian oral toxicity: subchronic Mammalian oral toxicity: chronic Studies relevant for mammalian toxicity reference value development for ingestion exposures Summary of Avian Toxicity Avian oral toxicity: acute Avian oral toxicity: subchronic Studies relevant for avian toxicity reference value development for ingestion exposures Summary of Amphibian Toxicity Amphibian toxicity Amphibian microcosm study Relevance for amphibian toxicity reference value development Summary of Reptilian Toxicity Reptilian toxicity: acute and subacute Reptilian toxicity: subchronic Recommended Toxicity Reference Values Toxicity reference values for mammals Toxicity reference values for birds Toxicity reference values for amphibians Toxicity reference values for reptiles References 25 26 28 28 29 30 31 35 35 35 36 37 37 39 40 42 42 42 42 42 45 46 47 48 INTRODUCTION Trinitrotoluene (TNT, 2, 4, 6-trinitrotoluene) is a nitroaromatic compound that is used extensively in military high explosives, and was largely used during World Wars I and II.
3 g/kg TNT, but none of the birds died thereafter during the study. Histopathology and sensitive indicators of immune function were evaluated. The effects included a dose-dependent and nonsignificant dampening of the total red blood cell count, packed cell volume, total plasma protein, blood prolymphocytes, blood lymphocytes, an increase in late apoptotic or necrotic blood leukocytes, and minor hemosiderosis of the liver. The authors noted that significant erythrolytic anemia was not the major target of toxicity in quail, which was most likely due to the refractory nature of the avian hematological and vascular system.
41] where no adverse effects were reported up to 59 mg TNT/kg soil. 78 mM; Induced malformation Changes in respiratory rhythm decrease in motor activities, salvation, and muscle tone changes, changes in skin color and ocular signs Mortality about 20%, decrease in body weight and snout vent lengths from lowest exposure concentration No adverse health effects were observed during 14-day exposure in soil matrix  Two salamanders died during the first week in 1,500 mg/kg and two others from 3000 mg/kg.