By James L. Schardein (Author), Orest T. Macina (Author)
Providing the 1st database of its variety, this specified reference illustrates the relationships among the chemistry and developmental toxicity of a couple of very important prescribed drugs and commercial toxicants. Human Developmental Toxicants includes up to date and concise info at the chemical buildings, houses, and organic actions for fifty identified brokers that adversely have an effect on prenatal and postnatal human improvement by way of progress, viability, constitution, and serve as. This publication offers information linking chemical and structural houses of particular toxicants as they relate to poisonous results, dosage, timing, and direction of publicity. targeting one compound in step with bankruptcy, the publication additionally comprises linked organic information from animals for every agent coated. An accompanying CD summarizes all the information mentioned within the textual content inside an digital database. furthermore, the CD comprises third-dimensional constitution representations and forty nine calculated physicochemical and topological parameters of the chosen molecules. this data turns out to be useful for construction constitution job dating (SAR) versions linking the chemical houses with saw human developmental toxicity. As scientists proceed to discover how chemical substances adjust human improvement, Human Developmental Toxicants comprises the mandatory details to extra establish which chemical houses are accountable for antagonistic results. This reference offers toxicologists, teratologists, chemists and different scientists with the newest info and data had to practice possibility checks, are expecting chemical compounds which may produce developmental toxicity, and keep watch over destructive publicity.
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Extra info for Human Developmental Toxicants: Aspects of Toxicology and Chemistry
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