IL-12 Receptor by Esche C., Shurin M.R., Lotze M.T.

By Esche C., Shurin M.R., Lotze M.T.

The sensible high-affinity IL-12 receptor consists of at the very least ♀-type receptor subunits, each one independently showing a low affinity for IL-12. either subunits are individuals of the cytokine receptor superfamily. IL-12 p40 interacts basically with IL-12 R♀1, whereas IL-12 p35 interacts basically with the signal-transducing ♀2 subunit. IL-12 signaling comprises activation of the receptor-associated tyrosine kinases JAK2 and TYK2 and downstream tyrosine phosphorylation of the transcription elements STAT3 and STAT4 (the imperative sign transducer of IL-12). The IL-12R is expressed totally on activated T andNK cells. Expression of the ♀2 subunit determines TH1 improvement because the ♀2 part is selectively downregulated on TH2 cells. Inhibiting IL-12 responsiveness represents an experimental remedy for TH1-driven inflammatory and autoimmune ailments.

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19 (1904), 374–425. 7. G. Bhowmik, D. Essouabri and B. , to appear. 8. R. , 128 (2001), 261–298. May 11, 2007 15:20 22 WSPC - Proceedings Trim Size: 9in x 6in ws-procs9x6 SHIGEKI EGAMI AND KOHJI MATSUMOTO 9. G. Dahlquist, On the analytic continuation of Eulerian products, Ark. , 1 (1952), 533–555. 10. S. Egami, Some curious Dirichlet series, S¯ urikaisekikenky¯ usho K¯ oky¯ uroku, 1091, RIMS Kyoto Univ. (1999), 172–174. 11. D. Essouabri, Singularit´es des s´eries de Dirichlet associ´ees ` a des polynˆ omes de plusieurs variables et applications ` a la th´eorie analytique des nombres, Th´ese, Univ.

Kluyver, Benaderingsformules betreffende de priemgetallen beneden eene gegeven grens, Koninglijke Akad. Wet. Amsterdam, Versl. Gew. Verg. Wis- en Natuur. , 8 (1900), 672–682. 24. N. Kurokawa, On the meromorphy of Euler products (I), Proc. London Math. , 209–236. ¨ 25. E. Landau, Uder die Multiplikation Dirichlet’scher Reihen, Rend. Circ. Mat. Palermo, 24 (1907), 81–160. ¨ 26. E. Landau and A. Walfisz, Uder die Nichtfortsetzbarkeit einiger durch Dirichletsche Reihen definierter Funktionen, ibid. 44 (1920), 82–86.

Hence we obtain Φ2 (s) = M (s − 1) − s−1 ρ Γ(s − ρ)Γ(ρ) M (s − ρ) − M (s) log 2π Γ(s) 1 + 2πi (−ε) Γ(s − z)Γ(z) M (s − z)M (z)dz. 9). 9) are clearly meromorphic on the whole plane. The poles of the third term coincide with the poles of M (s), which are s = 1 and s = ρ (non-trivial zeros). The poles of the first term are s = 2, s = ρ + 1, and s = 1. The residues of the first term at s = 2 and s = ρ + 1 are 1 and −n(ρ)/ρ, respectively. 9) is convergent uniformly in any compact subset of the half-plane s > 1 − ε, and hence holomorphic in that half-plane.

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