By Schrader J.W.
The receptor for IL-3 is made of subunits, either individuals of the cytokine receptor superfamily. The smaller ♂ subunit has a low affinity for IL-3 and the complicated of IL-3 and the ♂ subunit binds to the ♀ subunit to shape a high-affinity signaling advanced. The ♀ subunit is shared with the receptors for GM-CSF and IL-5, for that reason its identify, ♀ universal (♀c), and on my own, has no affinity for any of those 3 cytokines. within the mouse, despite the fact that, there's an extra, IL-3- particular ♀ subunit, that's encoded by way of a duplication of the ♀c gene and which has itself a low affinity for IL-3. Signaling downstream of the receptor complicated comprises activation of JAK2 kinase, tyrosine phosphorylation of ♀c and the initiation of signaling paths regulating progress, survival, and differentiation.
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10 a rule is defined for the vehicle entity that ensures that the number of audio systems installed shall be less or equal to the maximum allowed number. • Specialisation of inheritance relationships, the EXPRESS for the audio_system specifies that an audio system is either a CD system or a cassette system. This is stipulated by the oneof constraint defined for the entity audio_system. Alternatively inheritance relationships may be constrained with andor or and constraints. 10 then an audio_ system would be either a cassette system, a CD system or a combination thereof.
A document may be a physically bound book, collection of pages or may exist only in electronic form as one or more files on some electronic medium. More generally a document is a product of the documentation process and records information about some subject. , the engineering function or the material-handling function. Raw material A crude or processed material that can be converted by manufacture, processing, or combination with other raw materials and products into a new and useful product or raw material.
While conceptually sound the fact that AICs are based on integrated resources meant that overlaps with existing application protocols was often not discovered until late in the development process. Consequently costly harmonisation activities had to be launched late in the development process of some application protocols . The next approach in STEP was to develop a modularised approach where the modules are defined in both ARM and AIM. This approach forces an application protocol developer to consider the set of available modules 45 C HAPTER 2 before formalising domain specific requirements thus facilitate reuse of existing modules .