By Charles Orosz (auth.), David S. Wilkes M.D., William J. Burlingham Ph.D. (eds.)
Currently, contributors attracted to looking an in-depth dialogue of transplantation immunology needs to search person articles released in different journals, or extrapolate details from a variety of non-transplant immunology textbooks. the aim of this article is to supply the reader with a unmarried resource of data for the elemental technological know-how of immunobiology of organ transplantation. it's specified that it makes a speciality of immunobiology from the elemental examine aspect, with an emphasis at the mobile and molecular degrees.
The readers might be physicians, scientists, and graduate scholars and engaged within the examine of immunology because it pertains to allo- and xenotransplantation. This e-book is designed to be the reference usual for the immunobiology of transplantation.
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Extra info for Immunobiology of Organ Transplantation
Heeger (2002). Cross-primed CD8( +) T cells mediate graft rejection via a distinct effector pathway. Nat. Immunol. 3, 844. 65. Waldmann, H. (2002). Transplantation--caught in the crossfire! Nat. Immunol. 3, 803. 66. , A. S. Heeger (1999). Contributions of direct and indirect T-cell alloreactivity during allograft rejection in mice. J. Immunol. 162, 352. 67. J. and S. Sakaguchi (2003). Regulatory lymphocytes: Regulatory T cells in transplantation tolerance. Nat. Rev. Immunol. 3,199. 68. , A. K. Jenkins (1996).
Innate Immunity As it does not require prior sensitization, innate immunity provides the initial response to transplantation 14 . Early innate immune events may be essential for the induction of the adaptive immune response and its direction and may have important and underestimated long-term consequences on graft performance. 1. IschemialReperfusion Injury It is the reperfusion of warm recipient blood through an ischemic allograft that truly initiates the host immune response against the graft.
Lechler (2002). Pathways of allorecognition: Implications for transplantation tolerance. Transpl. Immunol. 10, 101. 54. J. and RI. Lechler (2001). Allorecognition. Am. J. Transplant. 1, 97. 55. A. and S. Chattopadhyay (1993). The molecular basis of allorecognition. Annu. Rev. Immunol. 11,385. 56. S. and H. Auchincloss, Jr. (1999). Direct and indirect recognition: The role of MHC antigens in graft rejection. Immunol. Today 20,77. 57. A. J. Wood (1994). Indirect presentation ofMHC antigens in transplantation.