Immunotoxicology and immunopharmacology by Robert V. House, Robert Luebke, Ian Kimber

By Robert V. House, Robert Luebke, Ian Kimber

Carrying on with the culture set through the 1st and moment variations, every one a bestseller in its personal correct, the 3rd variation of Immunotoxicology and Immunopharmacology offers studies of environmental brokers, up to date to mirror the newest info on how those brokers impression immune method functionality and future health. For the 1st time within the book's background, a complete part covers the phylogeny and ontogeny of the immune method, spanning degrees of organic complexity from earthworms to marine mammals.

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30 INTRODUCTION Regulatory approaches to immunotoxicology have evolved along with the science and therefore in most cases have been promulgated relatively recently. However, the origins of some regulatory test methods, such as those to identify potential for test article to produce allergic contact dermatitis, evolved with the science of immunology itself. [1] That is, xenobiotics that induce one type of adverse immune effect can modulate immune function in other often less predictable ways.

Anaphylaxis . . . . . . . . . . . . . . . . . . . . . . . . . . Systemic Hypersensitivity . . . . . . . . . . . . . . . . . . . . 21 22 22 23 24 25 26 Unintended Immunosuppression . . . . . . . . . . . . . . . . . . . . 28 Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30 References . . . . . . . . . . . . . . . . .

Keil, D. , Evaluation of multivariate statistical methods for analysis and modeling of immunotoxicology data, Toxicol. Sci. 51, 245, 1999. W. , Quantifying the relationship between multiple immunological parameters and host resistance: probing the limits of reductionism, J. , 167, 4543, 2001. Shkedy, Z. , Modeling anti-KLH ELISA data using two-stage and mixed effects models in support of immunotoxicological studies, J. Biopharm. , 15, 205, 2005. R, Current status and perspectives for the regulatory requirements in immunotoxicology, J.

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