Male-mediated Developmental Toxicity (Issues in Toxicology) by D. Anderson, M. Brinkworth

By D. Anderson, M. Brinkworth

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25 Self-reported data (by mothers) are similarly unreliable. 31 Furthermore, the four attributes occur together in the same individual more often than expected by chance – although it is rare for all four to be present: it has long been recognised that cryptorchidism is associated both with subfertility and with testicular cancer, and more recently it has become clear that men with testicular cancer are subfertile32 and have poor semen quality,33 even before the cancer is diagnosed. 35 There are some parallels in their descriptive epidemiology, implying that they probably share at least some risk factors, notably the sharp and consistent contrast between Finland and Denmark for the risk of all four endpoints.

25 Self-reported data (by mothers) are similarly unreliable. 31 Furthermore, the four attributes occur together in the same individual more often than expected by chance – although it is rare for all four to be present: it has long been recognised that cryptorchidism is associated both with subfertility and with testicular cancer, and more recently it has become clear that men with testicular cancer are subfertile32 and have poor semen quality,33 even before the cancer is diagnosed. 35 There are some parallels in their descriptive epidemiology, implying that they probably share at least some risk factors, notably the sharp and consistent contrast between Finland and Denmark for the risk of all four endpoints.

Numbers and standardized incidence ratios (SIRs) for cancer in the parents of 5863 children with cancer All sites (140–204) Buccal cavity and pharynx (140–148) Digestive organs (150–159) Respiratory system (160–164) Larynx (161) Lung (162) Breast (170) Female genital organs (171–176) Male genital organs (177–179) Prostate (177) Testis (178) Urinary system (180–181) Skin (190–191) Brain and nervous system (193) Bone and connective tissue (196–197) Lymphatic and haematopoietic tissues (200–205) Other specified organs (192, 194–195) Secondary and unspecified sites (198–199) Table 4 22 Chapter 3 23 Cancer in Siblings of Children with Cancer in the Nordic Countries Table 5 Standardized incidence ratios (SIRs) for breast cancer in mothers of children with osteogenic or soft-tissue sarcomas, according to the age of the child at diagnosis and the age of the mother Age of child at diagnosis (yr) 0–2 3–14 0–14 0–14 0–2 Age of mother (yr) All ages All ages o45 Z 45 o45 Obs.

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