By Ronald T. Acton, Charles M. Balch, Bruce Budowle (auth.), Ralph A. Reisfeld, Soldano Ferrone (eds.)
The ever-expanding learn on human melanoma has led to a number of technical and conceptual advances over the past few years. Serological, structural, and organic char acterization of human cancer constitutes one zone of study that has obtained consid erable recognition from researchers and clinicians and has generated new and interesting infor mation. during this quantity, we now have tried to gather paintings on themes that produced one of the most contemporary advances. We requested every one writer to explain and interpret his such a lot cur hire learn and, every time attainable, to match and distinction it with paintings of different inves tigators within the box. we've got been cautious to not impose our viewpoints other than in contri butions from our personal laboratories, in view that we wish to give you the reader with as many divergent and occasionally opposing viewpoints as possible. as a result, we haven't been overly all in favour of overlaps in a few person issues. we are hoping that this quantity will give you the reader with a well-balanced assessment of present difficulties and concepts in a par ticular zone of melanoma learn. we want to convey our because of all individuals for his or her well timed and extremely attention-grabbing manuscripts, and we in actual fact wish that the reader will take pleasure in this quantity and gain as a lot from it as we did. R. A. Reisfeld S. Ferrone los angeles Jolla ix Contents bankruptcy 1 Immunogenetics of cancer RONALD T. ACTON, CHARLES M. BALCH, BRUCE BUDOWLE, RODNEY C. P. pass, JEFFREY M. ROSEMAN, SENG-jAW SOONG, AND BRUCE O. BARGER 1. advent . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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188:732. INDOMETHACIN, PROSTAGLANDIN, AND IMMUNE REGULATION 33 Balch, C. , Murad, T. , Soong, S. , Ingalls, A. , Richards, P. , and Maddox, W. , 1979a, Tumor thickness as a guide to surgical management of clinical stage I melanoma patients, Cancer 43:883. Balch, C. , Soong, S. , Murad, T. , Ingalls, A. , and Maddox, W. , 1979b, A multifactorial analysis' of melanoma. II. Prognostic factors in patients with State I (Iocalized) melanoma, Surgery 86:343. Balch, C. , Dougherty, P. , and Tilden, A. , 1981a, Excessive prostaglandin E2 production by suppressor cells in head and neck cancer patients, Proceedings ASCOIAACR (in press).
1977, Statistical study on malignant melanoma in Japan (1970-1976), Tohoku J. Exp. Med. 121:355. , Illeni, M. , 1980, HLA antigens in malignant melanoma patients, Tumori 66:51. Reimer, R. , Clark, W. , Greene, M. , Ainsworth, A. , and Fraumeni, J. , 1978, Precursor lesions in familial melanoma: A new genetic preneoplastic syndrome, J. Am. Med. Assoc. 239:744. , 1976, Genetic loci of components of the classical and alternate pathway of complement activation: A new dimension of the immunogenetic linkage group (HLA) on chromosome 6 in man, Hum.
Immune regulation can take place by cell-cell contact between regulatory cells and effector cells as well as by release of soluble mediators. This chapter will focus on one important group of mediators: prostaglandin (PG) and other metabolic products of arachidonic acid that can regulate certain cellular immune responses. Such immunopharmacol- CHARLES M. BALCH AND ARABELLA B. TILDEN • Departments of Surgery and Microbiology; Cellular Immunobiology Unit, Comprehensive Cancer Center; Veterans Hospital, University of Alabama in Birmingham, Birmingham, Alabama 35294 23 24 CHARLES M.