Metallochemistry of neurodegeneration: biological, chemical, by Henryk Kozlowski;David R Brown;Gianni Valensin

By Henryk Kozlowski;David R Brown;Gianni Valensin

Bioinorganic chemistry has a move disciplinary technique, utilising the foundations of chemistry to organic structures. Metallochemistry of Neurodegeneration: organic, Chemical and Genetic elements discusses the speedily constructing region of metals within the fearful process and their position in neurodegenerative illness, similar to Alzheimer's, Parkinson's and prion ailments.

Written through best specialists of their fields, each one bankruptcy combines parts of genetics, biochemistry and organic inorganic chemistry in its dialogue. The booklet highlights the diversities in pathologies of neurodegenerative illnesses but additionally discusses the mechanistic similarities. Sections comprise: steel ions and prion illnesses; steel ions and Alzheimer ailment; manganese in mind functioning; steel involvement in Parkinson ailment; Cu-Zn superoxide dismutase and familial amyotrophic lateral sclerosis.

This publication will entice either chemists and biologists on the postgraduate and examine level. 

 

From a overview by way of Dennis Rouvray in Chemistry international, April 2007

This booklet units itself the duty of elucidating the habit of proteins within the mind, specifically exploring the joint affects of steel ions and oxidative rigidity on protein folding. the extent is suitable essentially for learn staff within the box even supposing i believe that almost all chemists will be in a position to learn this paintings with profit. 

… this booklet is scientifically sound and unusually wide-ranging in its assurance ... a necessary addition to the fairly sparse literature at the subject. 

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Sigel and H. Sigel (eds), Marcel Dekker, New York, 1999, 79. 7. O. Sergent, I. Morel and J. Cillard, in Metal Ions in Biological Systems, A. Sigel and H. Sigel (eds), Marcel Dekker, New York, 1999, 251. 8. K. A. Imlay, J. Biol. , 1997, 272, 27652. 9. K. A. Imley, Proc. Natl. Acad. , USA, 1996, 93, 13635. 10. E. B. Porter, Biochem. Soc. , 1996, 25, 75. 11. R. F. Matzanke, Biometals, 1995, 8, 223. 12. N. , Mol. , 1996, 20, 1127. 13. L. , 1996, 381, 131. 14. R. Gardner, Biosci. , 1997, 17, 33. 15.

Narita, F. Kawasaki and H. , 1990, 510, 289. D. A. Milanick, J. Am. , 1991, 261, C467. H. , Nature, 1997, 388, 482. S. , 2003, 24, 3. R. Connor, Dev. , 1994, 16, 233. A. Takeda, A. R. Connor, J. Neurosci. , 1998, 51, 454. L. , Mol. Chem. , 1997, 31, 207. H. Dussault and J. Ruel, Annu. Rev. , 1987, 49, 321. R. B. Bradbury, J. , 1990, 54, 905. M. W. , 1988, 462, 31. E. , Neurosurgery, 1980, 6, 45. J. , Neurotoxicology, 1994, 15, 897. H. Tja¨lve and J. Tallkvist, in Metal Ions and Deurodegenerative Disorders, P.

1999, 24, 427. A. , Meth. , 1999, 309, 746. K. , J. , 1998, 18, 8126. S. , Free Rad. Biol. , 2000, 29, 1085. X. , Biochim. Biophys. Acta, 2000, J. , 2000, 130, 1488S. R. Stadtman, Science, 1992, 257, 1220. D. , Proc. Natl. Acad. Sci. USA, 1991, 88, 10540. C. , Arch. Biochem. , 1997, 346, 74. Metal Ion-Induced Redox Reactions 70. 71. 72. 73. 74. 75. 76. 77. 78. 79. 80. 81. 82. 83. 84. 85. 86. 87. 88. 89. 90. 91. 92. 93. 94. 95. 96. 97. 98. 99. 100. 101. 102. 103. 104. 105. 106. 107. 108. 37 U.

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