By Marcel Gielen, Edward R. T. Tiekink
There are an striking quantity and diversity of roles that metals play in modern medication. This publication comprises info at the medicinal makes use of of inorganics, that's, of components corresponding to boron, lithium, selenium, to call a number of, in addition to metal-containing species.
according to the proposal that fit mammals depend on (bio-essential) metals for the traditional functioning of roughly a 3rd in their proteins and enzymes, plenty of medicines are metal-based and enormous attempt is being dedicated to constructing either moment- and third-generation medications in addition to producing novel metal-based medications. whereas there's no doubt that there's an emphasis on 'Metallotherapeutics' through the quantity, using metals in medication isn't really constrained to metal-based medicinal drugs. the next also are lined:
- non-invasive radiopharmaceuticals
- Magnetic Resonance Imaging (MRI)
- mineral vitamins
From the foregoing and, extra importantly, from the contents of a few of the Chapters, the reader will achieve an appreciation of the very genuine function metal-based medications play in glossy medication and of the significant attempt being dedicated to the advance of novel complexes with larger efficacy as healing and diagnostic brokers.
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Extra info for Metallotherapeutic Drugs and Metal-Based Diagnostic Agents: The Use of Metals in Medicine
1). 3–5 As magnesium ions interact with hundreds of proteins, this suggests that lithium may inhibit numerous enzymes. However, the relative specificity of the lithium effect suggests that only proteins with very low affinities for magnesium are targeted by therapeutic concentrations of the drug. 0 mM. 1 The chemical symbol, atomic charge and atomic number of lithium and its neighbouring elements on the periodic and their ionic radii table in different coordination states. Units are given in pico moles Symbol Charge Atomic no.
Neuroreport. 1998; 9: 2081. 2 5B Boron Compounds as Therapeutic Drugs Geeta Rana, Kamesh Vyakaranam, John A. Maguire and Narayan S. Hosmane Boron analogues of a variety of biologically important molecules have been found to play an increasingly important role in the areas of pharmacology, medicine, biochemistry and nutrition. Bearing close structural resemblance to their natural organic counterparts, the boron analogues exhibit potent biological activities. Compounds containing one or more boron atoms have been prepared for a variety of applications.
P53 promotes the expression of Bax, which is a pro-apoptotic gene Lithium Metallotherapeutics 14 whose product may cause the release of cytochrome c from the mitochondria and induce subsequent caspase activation and protein degradation. 66 Similarly, the product of the Bcl-2 gene is a cytoprotective protein, which interacts with the mitochondrial membrane to prevent Bax-induced cytochrome c release and the induction of this apoptotic pathway. 3 Ischemia (stroke) Animal models of stroke have been extensively used to examine possible therapeutic effects of lithium.