By Cristiana Tanase, Irina Ogrezeanu, Corin Badiu
The pituitary gland is a vital one because it controls numerous of the opposite hormone glands, comparable to the thyroid and adrenals. A pituitary adenoma is an irregular development or tumor during this gland, and they're the topic of very energetic medical and pathological research.
This e-book examines the newest advancements during this box and discusses crucial molecules implicated in apoptosis, angiogenesis and sign transduction. an outstanding knowing of those procedures is required to spot the easiest therapies.
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Extra info for Molecular Pathology of Pituitary Adenomas (Elsevier Insights)
Yoshida, D. and Teramoto, A. (2005) Expression of hypoxia-inducible factor 1alpha and vascular endothelial growth factor in pituitary adenomas. Endocr. , 16(2): 115–21. 20. V. W. (2003) Expression of hypoxia-inducible factor-1alpha (HIF-1alpha) in pituitary tumours. Histol. , 18(3): 679–86. 21. , et al. (2004) Analysis of Cox-2 and thromboxane synthase expression in pituitary adenomas and carcinomas. Endocr. , 15(1): 17–27. 22. , et al. (2003) Cyclooxygenase-2 (COX-2) and epidermal growth factor receptor (EGFR) expression in human pituitary macroadenomas.
Ang-1 acts as an agonist, whereas ang-2 acts as an antagonist but it can promote angiogenesis, especially in cooperation with VEGF. These angiopoietins act in concert with VEGF to stabilize and mature new capillaries. Blockade of this tie-2/ TEK (tyrosine kinase endothelial) pathway has been more difficult than blockade of the VEGF pathway, in part because of the complexity of agonistic and antagonistic ligands for the same receptor and the problems in finding effective and specific drugs against tie-2 or the angiopoietins.
And Teramoto, A. (2004) Correlation between tumor vascularity and clinical findings in patients with pituitary adenomas. Endocr. , 15(2): 131–39. 8. A. E. (2004) Morphologic changes and molecular regulation of angiogenesis in pituitary adenomas. Front. Horm. , 32: 133–45. 9. , Nawashiro, H. and Otani, N. (2003) Vascular endothelial growth factor expression in pituitary adenomas. Acta Neurochir. , 86: 519–21. 10. , Otani, N. and Nawashiro, H. (2003) The association of the expression of vascular endothelial growth factor with the cystic component and haemorrhage in pituitary adenoma.