Pathogenesis and Treatment of Diabetes Mellitus by J. K. Radder (auth.), J. K. Radder, H. H. P. J. Lemkes, H.

By J. K. Radder (auth.), J. K. Radder, H. H. P. J. Lemkes, H. M. J. Krans (eds.)

In this ebook on diabetes mellitus either the pathogenesis and deal with­ ment of the affliction can be mentioned. Pathogenetic reviews have resulted in the excellence among style I and sort II diabetes. In kind I hyperglycaemia is due predominantly to insulin deficiency; in kind II insulin resistance is extra very important. 3 pathogenetic elements are suggestion to play a task within the etiol­ ogy of kind I diabetes: heredity, viral infections and immunity. there is a courting among those 3 points due to the fact that genetic pre­ disposition alterations the susceptibility to viral infections and/or the immunological defence opposed to those infections. Insulitis ensues. car­ immune approaches initiated by means of this chain of occasions might give a contribution to the destruction of the B cells within the islets of Langerhans and diabetes -may ultimately persist with. which means on the time of the surprising out­ holiday of the illness, the harmful approach has already been energetic for years.

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16-52. KGMM Alberti and LP Krall (eds). Elsevier Science Publ. Amsterdam. Rodier H, Andary M, Richard JL, Hirouze J, Clot J (1984): Peripheral blood T-cell subsets studied by monoclonal antibodies in Type I (Insulin-dependent) diabetes: effect of blood glucose control. , 136-138. Jackson RA, Morris MA, Haynes BF, Eisenbarth GS (1982): Increased circulating Ia antigen-bearing T cells in Type I diabetes mellitus. N. Engl. J. , 306, 785-788. PozzilliP, Zuccarini 0, Iavicoli H, Andreani D, Sensi H, Spencer KM, Bottazzo GF, Beverley PCL, Kyner JL, Cudworth AG (1983): Monoclonal antibodies defined abnormalities of T lymphocytes in Type I (insulin-dependent) diabetes.

Diabetes, 31, 459-462. Kanatsuna ~ Freedman ZR, Rubenstein AH, Lernmark A (1982): Effect of islet cell surface antibodies and complement on the release of insulin and chromi urn from perifused Beta cells. Clin. Exp. , 47, 85-92. --- --KanatsunaT, Baekkeskov S, Lernmark A, Ludvigsson J (1983): Immunoglobulin from insulin dependent diabetic children inhibits glucose induced insulin release. Diabetes, 32, 520-524. Sai P, Boitard Chr, Debray-Sachs M, Pouplard~, Assan R, Hamburger J (1981): Complement fixing islet cell antibodies from some diabetic patients alter insulin release in vitro.

In: Autoimmune Endocrine Disease, pp. 167-180. Editor: TF Davies, John Wiley, New York. :!!. CHn. Invest. 2, 41-49. 24 16. 17. 18. 19. 20. 21. 22. 23. 24. 25. 26. 27. 28. 29. 30. 31. 32. Orci L (1982): Macro- and micro-domains in the endocrine pancreas. Diabetes, 31, 538-565. Dobersen MJ, Schaff JE, Ginsberg-Fellner F, Notkins, AL (1982): Preferential lysis of Beta cells by islet cell surface antibodies. Diabetes, 31, 459-462. Kanatsuna ~ Freedman ZR, Rubenstein AH, Lernmark A (1982): Effect of islet cell surface antibodies and complement on the release of insulin and chromi urn from perifused Beta cells.

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